{ "built": "2026-10-19 (ET)", "page": "https://jabbitapp.com/research/dmso-dimethyl-sulfoxide-als-pain-cancer-teardown.html", "clinicaltrials_gov": { "source": "ClinicalTrials.gov API v2, query.term = DMSO | dimethyl sulfoxide | dimethylsulfoxide | RIMSO-50 | dimexide (deduplicated by NCT)", "method": "Every study read by hand (title, arms, interventions, descriptions) and classified by the role DMSO plays. Lower bound: registries outside CT.gov not searched.", "summary": { "total_unique_studies": 183, "by_role": { "vehicle_or_penetration_enhancer_or_vehicle_arm": 20, "cryoprotectant_for_cells_or_tissue": 58, "drug_solvate_or_solvent": 43, "lab_or_background_mention_only": 42, "dmso_itself_is_the_treatment": 8, "dental_material": 7, "dmso_based_combination": 5 }, "dmso_as_treatment_or_dmso_based_combo": 13, "of_which_with_posted_results": 2, "of_which_interstitial_cystitis": 6, "studies_mentioning_als_anywhere": [ "NCT06281847" ], "dmso_treatment_studies_for_als": 0, "dmso_treatment_studies_for_pain_or_arthritis_alone": 0, "dmso_treatment_studies_for_cancer": [ "NCT04279535", "NCT05932511" ] }, "treatment_rows": [ { "nct": "NCT03103594", "title": "Comparison of the Treatment of Refractory Bladder Pain Syndrome With DMSO and DMSO With Botulinum Toxin A", "role": "dmso_itself_is_the_treatment", "dmso_use": "interstitial cystitis", "conditions": [ "Bladder Pain Syndrome" ], "status": "COMPLETED", "has_results": false, "phase": [ "EARLY_PHASE1" ], "enrollment": 2, "allocation": "RANDOMIZED", "sponsor": "University of Pennsylvania", "start": "2015-08", "first_submitted": "2017-03-31", "mentions_als": false }, { "nct": "NCT05560919", "title": "Acceleration of Orthodontic Tooth Movement", "role": "dmso_itself_is_the_treatment", "dmso_use": "orthodontic tooth movement", "conditions": [ "Mild to Moderate Anterior Mandibular Segment Crowdind" ], "status": "COMPLETED", "has_results": false, "phase": [ "PHASE2", "PHASE3" ], "enrollment": 18, "allocation": "RANDOMIZED", "sponsor": "Latakia University", "start": "2021-09-20", "first_submitted": "2022-09-26", "mentions_als": false }, { "nct": "NCT01074567", "title": "DMSO Efficacy in IC/PBS Patients During and After Treatment", "role": "dmso_itself_is_the_treatment", "dmso_use": "interstitial cystitis", "conditions": [ "Cystitis, Interstitial" ], "status": "UNKNOWN", "has_results": false, "phase": [ "NA" ], "enrollment": 50, "allocation": "NA", "sponsor": "Assaf-Harofeh Medical Center", "start": "2009-12", "first_submitted": "2010-02-23", "mentions_als": false }, { "nct": "NCT07567274", "title": "DMSO Dual-Route Therapy for Refractory Tinnitus in Long-COVID and Post-COVID-19 Vaccine Injury", "role": "dmso_based_combination", "dmso_use": "tinnitus after COVID / COVID vaccine (compounded DMSO otic + cream with betahistine, dexamethasone, lidocaine)", "conditions": [ "Tinnitus" ], "status": "ENROLLING_BY_INVITATION", "has_results": false, "phase": [ "PHASE2" ], "enrollment": 20, "allocation": "NA", "sponsor": "Leading Edge Clinic", "start": "2026-05-15", "first_submitted": "2026-05-01", "mentions_als": false }, { "nct": "NCT05223244", "title": "Bladder Capacity as Objective Measure of Intravesical Treatment of Newly Diagnosed IC", "role": "dmso_itself_is_the_treatment", "dmso_use": "interstitial cystitis", "conditions": [ "Interstitial Cystitis", "Painful Bladder Syndrome" ], "status": "COMPLETED", "has_results": false, "phase": [ "PHASE4" ], "enrollment": 83, "allocation": "RANDOMIZED", "sponsor": "Endeavor Health", "start": "2011-10-01", "first_submitted": "2022-01-24", "mentions_als": false }, { "nct": "NCT04268810", "title": "Prospective Trial Comparing Intravesical Chondroitin Sulphate 2% and DMSO in the Treatment of PBS/Interstitial Cystitis", "role": "dmso_itself_is_the_treatment", "dmso_use": "interstitial cystitis", "conditions": [ "Painful Bladder Syndrome", "Interstitial Cystitis" ], "status": "TERMINATED", "has_results": false, "phase": [ "PHASE4" ], "enrollment": 36, "allocation": "RANDOMIZED", "sponsor": "National Multiple Sclerosis Center", "start": "2010-03", "first_submitted": "2013-03-31", "mentions_als": false }, { "nct": "NCT01069263", "title": "Comparative Study Between Hyperbaric Therapy and Intravesical Dimethyl Sulfoxide Instillation for Interstitial Cystitis", "role": "dmso_itself_is_the_treatment", "dmso_use": "interstitial cystitis", "conditions": [ "Interstitial Cystitis" ], "status": "UNKNOWN", "has_results": false, "phase": [ "NA" ], "enrollment": 60, "allocation": "RANDOMIZED", "sponsor": "Assaf-Harofeh Medical Center", "start": "2010-02", "first_submitted": "2010-01-10", "mentions_als": false }, { "nct": "NCT00583219", "title": "Botulin-A Toxin Instillations and Overactive Bladder", "role": "dmso_based_combination", "dmso_use": "overactive bladder (botulinum toxin carried in DMSO)", "conditions": [ "Overactive Bladder", "Detrusor Instability", "Detrusor Hyperreflexia" ], "status": "COMPLETED", "has_results": true, "phase": [ "PHASE1", "PHASE2" ], "enrollment": 25, "allocation": "NA", "sponsor": "Mayo Clinic", "start": "2006-03", "first_submitted": "2007-12-20", "mentions_als": false }, { "nct": "NCT04279535", "title": "Topical Vitamin C for Treatment of Basal Cell Cancer", "role": "dmso_based_combination", "dmso_use": "basal cell carcinoma (30% ascorbic acid in DMSO)", "conditions": [ "Basal Cell Carcinoma" ], "status": "COMPLETED", "has_results": false, "phase": [ "EARLY_PHASE1" ], "enrollment": 25, "allocation": "RANDOMIZED", "sponsor": "Center for Biomedical Research, Inc.", "start": "2018-03-01", "first_submitted": "2020-02-19", "mentions_als": false }, { "nct": "NCT00667095", "title": "Over Active Bladder Instillation Study - Botox", "role": "dmso_based_combination", "dmso_use": "overactive bladder (botulinum toxin carried in DMSO)", "conditions": [ "Overactive Bladder", "Urinary Urge Incontinence", "Urinary Incontinence", "Detrusor Hyperreflexia", "Urge Incontinence" ], "status": "TERMINATED", "has_results": true, "phase": [ "PHASE3" ], "enrollment": 25, "allocation": "RANDOMIZED", "sponsor": "Mayo Clinic", "start": "2008-04", "first_submitted": "2008-04-23", "mentions_als": false }, { "nct": "NCT02206477", "title": "DMSO for Prevention of Capsular Contraction in Alloplastic Breast Reconstruction", "role": "dmso_itself_is_the_treatment", "dmso_use": "breast implant capsular contracture", 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"vehicle_or_penetration_enhancer_or_vehicle_arm", "status": "ACTIVE_NOT_RECRUITING", "has_results": false, "enrollment": 40 }, { "nct": "NCT06001853", "role": "cryoprotectant_for_cells_or_tissue", "status": "ACTIVE_NOT_RECRUITING", "has_results": false, "enrollment": 40 }, { "nct": "NCT06003530", "role": "cryoprotectant_for_cells_or_tissue", "status": "UNKNOWN", "has_results": false, "enrollment": 21 }, { "nct": "NCT06157619", "role": "cryoprotectant_for_cells_or_tissue", "status": "UNKNOWN", "has_results": false, "enrollment": 20 }, { "nct": "NCT06208241", "role": "cryoprotectant_for_cells_or_tissue", "status": "ACTIVE_NOT_RECRUITING", "has_results": false, "enrollment": 18 }, { "nct": "NCT06240416", "role": "lab_or_background_mention_only", "status": "UNKNOWN", "has_results": false, "enrollment": 30 }, { "nct": "NCT06248697", "role": "cryoprotectant_for_cells_or_tissue", "status": "RECRUITING", "has_results": false, "enrollment": 16 }, { "nct": "NCT06252337", "role": "dental_material", "status": "ACTIVE_NOT_RECRUITING", "has_results": false, "enrollment": 80 }, { "nct": "NCT06281847", "role": "cryoprotectant_for_cells_or_tissue", "status": "NOT_YET_RECRUITING", "has_results": false, "enrollment": 143 }, { "nct": "NCT06635382", "role": "dental_material", "status": "NOT_YET_RECRUITING", "has_results": false, "enrollment": 68 }, { "nct": "NCT06724471", "role": "cryoprotectant_for_cells_or_tissue", "status": "ACTIVE_NOT_RECRUITING", "has_results": false, "enrollment": 30 }, { "nct": "NCT06778434", "role": "vehicle_or_penetration_enhancer_or_vehicle_arm", "status": "RECRUITING", "has_results": false, "enrollment": 48 }, { "nct": "NCT06805448", "role": "cryoprotectant_for_cells_or_tissue", "status": "RECRUITING", "has_results": false, "enrollment": 40 }, { "nct": "NCT06805890", "role": "lab_or_background_mention_only", "status": "RECRUITING", "has_results": false, "enrollment": 60 }, { "nct": "NCT06810258", "role": "lab_or_background_mention_only", "status": "RECRUITING", "has_results": false, "enrollment": 1000 }, { "nct": "NCT06883188", "role": "lab_or_background_mention_only", "status": "NOT_YET_RECRUITING", "has_results": false, "enrollment": 30 }, { "nct": "NCT06938334", "role": "cryoprotectant_for_cells_or_tissue", "status": "NOT_YET_RECRUITING", "has_results": false, "enrollment": 15 }, { "nct": "NCT07020715", "role": "cryoprotectant_for_cells_or_tissue", "status": "NOT_YET_RECRUITING", "has_results": false, "enrollment": 14 }, { "nct": "NCT07110246", "role": "drug_solvate_or_solvent", "status": "RECRUITING", "has_results": false, "enrollment": 96 }, { "nct": "NCT07196618", "role": "dental_material", "status": "COMPLETED", "has_results": false, "enrollment": 30 }, { "nct": "NCT07255508", "role": "drug_solvate_or_solvent", "status": "NOT_YET_RECRUITING", "has_results": false, "enrollment": 100 }, { "nct": "NCT07290946", "role": "cryoprotectant_for_cells_or_tissue", "status": "NOT_YET_RECRUITING", "has_results": false, "enrollment": 100 }, { "nct": "NCT07321028", "role": "lab_or_background_mention_only", "status": "ENROLLING_BY_INVITATION", "has_results": false, "enrollment": 50 }, { "nct": "NCT07479290", "role": "vehicle_or_penetration_enhancer_or_vehicle_arm", "status": "RECRUITING", "has_results": false, "enrollment": 30 }, { "nct": "NCT07567274", "role": "dmso_based_combination", "status": "ENROLLING_BY_INVITATION", "has_results": false, "enrollment": 20 }, { "nct": "NCT07672483", "role": "cryoprotectant_for_cells_or_tissue", "status": "RECRUITING", "has_results": false, "enrollment": 95 }, { "nct": "NCT07796854", "role": "lab_or_background_mention_only", "status": "NOT_YET_RECRUITING", "has_results": false, "enrollment": 100 }, { "nct": "NCT07802600", "role": "lab_or_background_mention_only", "status": "NOT_YET_RECRUITING", "has_results": false, "enrollment": 100 }, { "nct": "NCT07830641", "role": "dental_material", "status": "COMPLETED", "has_results": false, "enrollment": 30 }, { "nct": "NCT07842120", "role": "dental_material", "status": "RECRUITING", "has_results": false, "enrollment": 60 } ] }, "pubmed": { "query": "(\"Dimethyl Sulfoxide\"[MeSH] OR DMSO[tiab] OR \"dimethyl sulfoxide\"[tiab] OR dimethylsulfoxide[tiab] OR \"dimethyl sulphoxide\"[tiab]) AND (Randomized Controlled Trial[pt])", "pulled": "2026-10-19 20:59 CDT", "records_tagged_rct": 169, "human_rcts_testing_dmso_itself": 35, "by_area": { "bladder": 7, "musculoskeletal pain": 9, "skin and wounds": 5, "gut disease and cancer survival (one author)": 14 }, "single_author_salim_series": 14, "cancer_survival_trials": [ "8493453", "1591948", "1591947" ], "als_trials": 0, "dmso_based_combinations": { "35217280": "30% ascorbic acid in 95% DMSO vs imiquimod, basal cell carcinoma (25 people, 29 lesions)", "1055560": "DMSO-containing anti-inflammatory spray, infant bronchiolitis", "39085322": "phytoterpenes in DMSO vs placebo, plantar fasciitis" }, "other_records_note": "The rest use DMSO as a cryoprotectant, solvent, vehicle or dental primer; test MSM (methylsulfonylmethane, a different compound); are animal or lab studies; or are secondary/duplicate reports (e.g. PMID 12515575 cost analysis, 16013288 duplicate of 17553503, 23485788 HBO after DMSO).", "classified": [ { "pmid": "3288775", "area": "bladder", "finding": "DMSO vs saline, crossover, 33 people: 53% vs 18% markedly improved (subjective)", "title": "A controlled study of dimethyl sulfoxide in interstitial cystitis." }, { "pmid": "11061879", "area": "bladder", "finding": "DMSO vs BCG, crossover, 21 people: pain fell on DMSO; BCG no benefit", "title": "Intravesical bacillus Calmette-Guerin and dimethyl sulfoxide for treatment of classic and nonulcer interstitial cystitis: a prospective, randomized double-blind study." }, { "pmid": "19137459", "area": "bladder", "finding": "four treatments; more responded to DMSO than BCG on global response", "title": "Evaluation of health-related quality of life in patients with painful bladder syndrome/interstitial cystitis and the impact of four treatments on it." }, { "pmid": "27654012", "area": "bladder", "finding": "HA/CS vs DMSO, open label, 110 women, IBSA-sponsored: HA/CS better on pain at 6 months", "title": "A randomized, open-label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis." }, { "pmid": "28124536", "area": "bladder", "finding": "CS vs DMSO, 36 people: 57% of DMSO arm withdrew (pain, garlic odor, no effect); stopped early", "title": "A prospective randomized controlled multicentre trial comparing intravesical DMSO and chondroïtin sulphate 2% for painful bladder syndrome/interstitial cystitis." }, { "pmid": "33580603", "area": "bladder", "finding": "KRP-116D 50% DMSO vs placebo, Japan, 96 people: ICSI -5.2 vs -3.4", "title": "Efficacy and safety of intravesical instillation of KRP-116D (50% dimethyl sulfoxide solution) for interstitial cystitis/bladder pain syndrome in Japanese patients: A multicenter, randomized, double-blind, placebo-controlled, clinical study." }, { "pmid": "36747494", "area": "bladder", "finding": "DMSO + triamcinolone vs BTH, 83 randomized: 63% vs 43% responders, p=0.15", "title": "A prospective, randomized trial comparing intravesical dimethyl sulfoxide (DMSO) to bupivacaine, triamcinolone, and heparin (BTH), for newly diagnosed interstitial cystitis/painful bladder syndrome (IC/PBS)." }, { "pmid": "8529985", "area": "musculoskeletal pain", "finding": "25% DMSO gel vs gel base, knee osteoarthritis, 112 people, 3 weeks: less pain on loading", "title": "[DMSO in patients with active gonarthrosis. A double-blind placebo controlled phase III study]." }, { "pmid": "8194818", "area": "musculoskeletal pain", "finding": "10% DMSO gel (Rheumabene) vs gel base, acute tendon pain, 157 people: 44% vs 9% pain-free at 14 days", "title": "[Dimethylsulfoxide (DMSO) gel in treatment of acute tendopathies. A multicenter, placebo-controlled, randomized study]." }, { "pmid": "8721469", "area": "musculoskeletal pain", "finding": "50% DMSO cream vs placebo, acute reflex sympathetic dystrophy, 32 people: DMSO better", "title": "Treatment of acute reflex sympathetic dystrophy with DMSO 50% in a fatty cream." }, { "pmid": "12670672", "area": "musculoskeletal pain", "finding": "50% DMSO vs N-acetylcysteine, CRPS I, 146 people: no overall difference", "title": "The treatment of complex regional pain syndrome type I with free radical scavengers: a randomized controlled study." }, { "pmid": "8172505", "area": "musculoskeletal pain", "finding": "DMSO vs guanethidine blocks, RSD, 26 people: DMSO better at 9 weeks", "title": "Reflex sympathetic dystrophy: early treatment and psychological aspects." }, { "pmid": "2700237", "area": "musculoskeletal pain", "finding": "Dimexide 50% applications vs physiotherapy, rheumatoid arthritis (USSR, 1989)", "title": "[An evaluation of the efficacy of treating rheumatoid arthritis with preparations for local use]." }, { "pmid": "2697951", "area": "musculoskeletal pain", "finding": "DMSO in 42 people with rheumatic diseases; fibrin and microcirculation measures", "title": "[The effect of dimethyl sulfoxide on the thromboelastographic indices and the microcirculation in patients with rheumatic diseases]." }, { "pmid": "19380203", "area": "musculoskeletal pain", "finding": "Simon 2009: 45.5% DMSO vehicle vs 2.3% DMSO placebo, knee OA, 775 people in 5 arms: vehicle no better than placebo", "title": "Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritis." }, { "pmid": "15313991", "area": "musculoskeletal pain", "finding": "Bookman 2004: 45.5% DMSO vehicle vs placebo, knee OA, 248 people: pain change -2.5 vs -2.5", "title": "Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial." }, { "pmid": "3884019", "area": "skin and wounds", "finding": "2% and 70% DMSO vs saline, scleroderma finger ulcers, 84 people: no difference; >1/4 on 70% withdrawn for skin toxicity", "title": "Double-blind, multicenter controlled trial comparing topical dimethyl sulfoxide and normal saline for treatment of hand ulcers in patients with systemic sclerosis." }, { "pmid": "17553503", "area": "skin and wounds", "finding": "massage with DMSO cream vs plain cream vs repositioning, pressure ulcers: no difference", "title": "The effectiveness of massage with and without dimethyl sulfoxide in preventing pressure ulcers: a randomized, double-blind cross-over trial in patients prone to pressure ulcers." }, { "pmid": "16018522", "area": "skin and wounds", "finding": "topical DMSO vs none, mastectomy flap edge necrosis: less necrosis", "title": "Prevention of wound edge necrosis by local application of dimethylsulfoxide." }, { "pmid": "8857862", "area": "skin and wounds", "finding": "topical DMSO vs none, surgical skin flaps: less ischemia", "title": "Improved outcome of surgical flaps treated with topical dimethylsulfoxide." }, { "pmid": "32160368", "area": "skin and wounds", "finding": "50% DMSO vs tretinoin, macular amyloidosis, 18 people, split-body", "title": "Efficacy of topical dimethyl sulfoxide (DMSO) 50% solution vs tretinoin 0.5% cream in treatment of patients with primary macular amyloidosis: A split-side single-blinded randomized clinical trial." }, { "pmid": "8493453", "area": "gut disease and cancer survival (one author)", "finding": "oral DMSO or allopurinol vs control after palliative surgery for Dukes D colon cancer: 306 randomized, 193 evaluable; survival advantage", "title": "Scavengers of oxygen-derived free radicals prolong survival in advanced colonic cancer. A new approach." }, { "pmid": "1591948", "area": "gut disease and cancer survival (one author)", "finding": "oral DMSO or allopurinol vs control after gastrectomy for gastric cancer: 228 randomized, 160 evaluable; survival advantage", "title": "Oxygen-derived free-radical scavengers prolong survival in gastric cancer." }, { "pmid": "1591947", "area": "gut disease and cancer survival (one author)", "finding": "oral DMSO or allopurinol vs control after surgery for Dukes C colon cancer: 198 randomized, 144 evaluable; survival advantage", "title": "Oxygen-derived free-radical scavengers prolong survival in colonic cancer." }, { "pmid": "8277768", "area": "gut disease and cancer survival (one author)", "finding": "refractory duodenal ulcer", "title": "Role of free radical scavengers in the management of refractory duodenal ulceration. 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