{
 "checked": "2026-10-20",
 "intake_math": {
  "method": "NDNS non-wholemeal flour intake (FSS 2017 Table 5) x 2.5 ug/g x (1-0.25 production loss) x (1-0.113 imported)",
  "factor_ug_per_g_eaten": 1.6631,
  "groups": {
   "Everyone (average)": {
    "flour_g_day": 59,
    "nominal_ug_day": 147.5,
    "after_losses_ug_day": 98.1,
    "pct_of_400ug_supplement": 25,
    "pct_of_1000ug_upper_level": 10
   },
   "Women 19-34": {
    "flour_g_day": 56,
    "nominal_ug_day": 140.0,
    "after_losses_ug_day": 93.1,
    "pct_of_400ug_supplement": 23,
    "pct_of_1000ug_upper_level": 9
   },
   "Women 35-49": {
    "flour_g_day": 48,
    "nominal_ug_day": 120.0,
    "after_losses_ug_day": 79.8,
    "pct_of_400ug_supplement": 20,
    "pct_of_1000ug_upper_level": 8
   },
   "Men 19-34": {
    "flour_g_day": 78,
    "nominal_ug_day": 195.0,
    "after_losses_ug_day": 129.7,
    "pct_of_400ug_supplement": 32,
    "pct_of_1000ug_upper_level": 13
   },
   "Boys 14-18": {
    "flour_g_day": 82,
    "nominal_ug_day": 205.0,
    "after_losses_ug_day": 136.4,
    "pct_of_400ug_supplement": 34,
    "pct_of_1000ug_upper_level": 14
   },
   "Adults 65+": {
    "flour_g_day": 53,
    "nominal_ug_day": 132.5,
    "after_losses_ug_day": 88.1,
    "pct_of_400ug_supplement": 22,
    "pct_of_1000ug_upper_level": 9
   }
  },
  "fss_table8_crosscheck_ug_day": {
   "Everyone (average)": 97.5,
   "Women 19-34": 92.5,
   "Women 35-49": 80.0
  },
  "fss_mean_folic_acid_ug_day_before_after": [
   79,
   176
  ],
  "fss_pct_below_rni_total_folate_before_after": [
   29.8,
   7.4
  ],
  "flour_g_day_to_reach_1000ug_nominal": 400.0,
  "flour_g_day_to_reach_1000ug_after_losses": 601
 },
 "above_upper_level_pct": {
  "now": 0.42,
  "after_250_no_restrictions": 0.635,
  "after_250_with_restrictions_on_cereals_spreads_supplements": 0.07
 },
 "impact_assessment_ntd": {
  "terminations_prevented_england": 112,
  "births_with_ntd_prevented": 31,
  "miscarriages_prevented_england": 6,
  "terminations_now_england": 591,
  "live_ntd_births_now_england": 165,
  "miscarriages_now_england": 33,
  "risk_reduction_central_pct": 19,
  "risk_reduction_range_pct": [
   12,
   27
  ],
  "daly_pct": 15.4,
  "crider_pct": 22.4
 },
 "petition": {
  "id": 769589,
  "signatures": 117907,
  "uk_signatures": 116742,
  "opened_at": "2026-06-08T14:36:09.331Z",
  "debate_threshold_reached_at": "2026-10-08T18:12:20.000Z",
  "government_response_at": "2026-06-29T12:21:00.293Z",
  "scheduled_debate_date": null,
  "creator": "Dr Clare Craig",
  "earlier_petition_751401_signatures": 24140,
  "checked_et": "10:21 AM ET"
 },
 "national_levels": [
  {
   "country": "United Kingdom",
   "ug_per_100g": 250,
   "flour": "Non-wholemeal common wheat flour",
   "since": "Dec 13, 2026",
   "ntd_change": "19% fewer (modelled; range 12-27%)"
  },
  {
   "country": "Chile",
   "ug_per_100g": 220,
   "flour": "Wheat flour",
   "since": "2000",
   "ntd_change": "not checked"
  },
  {
   "country": "United States",
   "ug_per_100g": 154,
   "flour": "Enriched flour (FDA policy: 140 ug/100 g cereal-grain product)",
   "since": "Jan 1998",
   "ntd_change": "28% fewer (35% where prenatal diagnoses counted)"
  },
  {
   "country": "Canada",
   "ug_per_100g": 150,
   "flour": "White flour",
   "since": "1998",
   "ntd_change": "46% fewer"
  }
 ],
 "ctgov": {
  "umfa_query": "\"unmetabolized folic acid\" OR \"unmetabolised folic acid\" OR UMFA",
  "umfa_studies": [
   {
    "nct": "NCT04011345",
    "title": "Folic Acid Supplementation in Children With Sickle Cell Disease",
    "has_results": false,
    "registers_cancer_outcome": false,
    "registers_cognitive_outcome": false
   },
   {
    "nct": "NCT05673070",
    "title": "Use of Ritual Prenatal Multivitamins for Pregnancy",
    "has_results": false,
    "registers_cancer_outcome": false,
    "registers_cognitive_outcome": false
   },
   {
    "nct": "NCT06223854",
    "title": "Acceptability and Nutritional Impact of Double-fortified Salt Containing Iodine and Folic Acid",
    "has_results": false,
    "registers_cancer_outcome": false,
    "registers_cognitive_outcome": false
   },
   {
    "nct": "NCT07163962",
    "title": "THE B-BABIES STUDY: An Observational Study of Group B Vitamins in Preterm Infants",
    "has_results": false,
    "registers_cancer_outcome": false,
    "registers_cognitive_outcome": false
   },
   {
    "nct": "NCT04310059",
    "title": "Effect of Folic Acid Supplementation in Pregnant Women Having Thalassaemia Trait",
    "has_results": false,
    "registers_cancer_outcome": false,
    "registers_cognitive_outcome": false
   },
   {
    "nct": "NCT06935630",
    "title": "Comparison of The Effect of 5-MTHF and Folic Acid Supplementation in Increasing Red Blood Cell Folate in Pregnant Women",
    "has_results": false,
    "registers_cancer_outcome": false,
    "registers_cognitive_outcome": false
   },
   {
    "nct": "NCT06641245",
    "title": "PREconception Folic Acid Clinical Efficacy (PREFACE) Trial",
    "has_results": false,
    "registers_cancer_outcome": false,
    "registers_cognitive_outcome": false
   },
   {
    "nct": "NCT04022135",
    "title": "Natural Folate vs. Synthetic Folic Acid in Pregnancy",
    "has_results": false,
    "registers_cancer_outcome": false,
    "registers_cognitive_outcome": false
   },
   {
    "nct": "NCT03981029",
    "title": "FACT Biomarker Subgroup Analysis",
    "has_results": true,
    "registers_cancer_outcome": false,
    "registers_cognitive_outcome": false
   },
   {
    "nct": "NCT03472820",
    "title": "Methylation Diet and Lifestyle Study",
    "has_results": false,
    "registers_cancer_outcome": false,
    "registers_cognitive_outcome": false
   }
  ],
  "fortification_query_total": 88,
  "fortification_with_results": 4,
  "folic_acid_flour_or_bread_trials": [
   {
    "nct": "NCT06100146",
    "title": "Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls",
    "registers_cancer_outcome": false
   },
   {
    "nct": "NCT00353353",
    "title": "The Bread Trial: Effects of Bread Fortified With Folic Acid and Vitamin B12",
    "registers_cancer_outcome": false
   },
   {
    "nct": "NCT01570088",
    "title": "Bioavailability of Folic Acid Fortified Bread",
    "registers_cancer_outcome": false
   }
  ]
 },
 "pubmed_counts": {
  "umfa_all": {
   "query": "\"unmetabolized folic acid\"[tiab] OR \"unmetabolised folic acid\"[tiab]",
   "count": 124
  },
  "umfa_rct": {
   "query": "(\"unmetabolized folic acid\"[tiab] OR \"unmetabolised folic acid\"[tiab]) AND randomized controlled trial[pt]",
   "count": 17
  },
  "umfa_rct_outcome_disease": {
   "query": "(\"unmetabolized folic acid\"[tiab] OR \"unmetabolised folic acid\"[tiab]) AND randomized controlled trial[pt] AND (cancer[tiab] OR cognit*[tiab] OR \"B12\"[tiab] OR \"B-12\"[tiab])",
   "count": 3
  },
  "fortification_ntd": {
   "query": "\"folic acid\"[tiab] AND fortif*[tiab] AND \"neural tube\"[tiab]",
   "count": 820
  },
  "fortification_cancer": {
   "query": "\"folic acid\"[tiab] AND fortif*[tiab] AND (cancer[tiab] OR neoplasm*[tiab])",
   "count": 178
  }
 },
 "x_counts": {
  "pulled_at": "2026-10-20T13:59Z (9:59 AM ET)",
  "q_flour": {
   "query": "(\"folic acid\" OR folate) (flour OR bread OR fortification OR petition) lang:en -is:retweet",
   "days_utc": {
    "2026-10-13 (from 14:05)": 154,
    "2026-10-14": 176,
    "2026-10-15": 193,
    "2026-10-16": 175,
    "2026-10-17": 143,
    "2026-10-18": 104,
    "2026-10-19": 173,
    "2026-10-20 (to 13:59)": 58
   },
   "total": 1176
  },
  "q_all": {
   "query": "\"folic acid\" lang:en -is:retweet",
   "days_utc": {
    "2026-10-13 (from 14:05)": 424,
    "2026-10-14": 658,
    "2026-10-15": 945,
    "2026-10-16": 721,
    "2026-10-17": 569,
    "2026-10-18": 447,
    "2026-10-19": 623,
    "2026-10-20 (to 13:59)": 239
   },
   "total": 4626
  }
 }
}