{
 "pulled_et": "2026-10-23 ~2:05 AM ET",
 "method": "Hand review of ops/data/glp1-face/ctgov-raw.json (from glp1_face_ctgov.py), 2026-10-23 ET, plus number checks\nagainst saved source text in ops/data/glp1-face/ (PubMed abstracts, PMC full text, FDA labels).\nKept: studies on ClinicalTrials.gov that enroll people taking a GLP-1 drug and measure the face or skin.\nExcluded: the other records, which matched only on words such as \"filler\" (cod fillet), \"face-to-face\", or facial\nflushing/headache, and are not about appearance.",
 "ctgov_query": [
  "(semaglutide OR tirzepatide OR \"GLP-1\" OR GLP1 OR Ozempic OR Wegovy OR Mounjaro OR Zepbound) AND (face OR facial OR cheek OR midface OR \"Ozempic face\" OR filler OR \"skin laxity\" OR \"skin quality\")"
 ],
 "ctgov_records_matching": 53,
 "kept_glp1_face_or_skin": 10,
 "kept_testing_a_cosmetic_treatment": 9,
 "kept_fillers_or_biostimulators": 5,
 "kept_devices": 2,
 "kept_topicals": 2,
 "kept_with_posted_results": 0,
 "kept_randomized": 2,
 "kept_sponsor_industry_or_private_practice": 9,
 "kept_comparing_drug_vs_equal_weight_loss_without_drug": 0,
 "label_terms_searched": [
  "facial fat",
  "facial volume",
  "facial wasting",
  "lipoatrophy",
  "facial aging",
  "gaunt",
  "ozempic face"
 ],
 "label_term_hits_wegovy_zepbound": {
  "facial fat": [
   0,
   0
  ],
  "facial volume": [
   0,
   0
  ],
  "facial wasting": [
   0,
   0
  ],
  "lipoatrophy": [
   0,
   0
  ],
  "facial aging": [
   0,
   0
  ],
  "gaunt": [
   0,
   0
  ],
  "ozempic face": [
   0,
   0
  ]
 },
 "studies": [
  {
   "nct": "NCT06351358",
   "title": "Evaluation of the Effects of a Biostimulator and Dermal Fillers for Cheek Augmentation and Contour Deficiencies",
   "tests": "Sculptra (PLLA) + Restylane Lyft or Contour (HA filler)",
   "kind": "filler/biostimulator",
   "area": "face",
   "comparison": "none",
   "status": "COMPLETED",
   "study_type": "INTERVENTIONAL",
   "allocation": "NA",
   "enrollment": 41,
   "primary_completion": "2025-05-31",
   "sponsor": "Galderma R&D",
   "sponsor_class": "INDUSTRY",
   "has_results": false,
   "primary_outcomes": [
    "Change in skin hydration from baseline",
    "Change in skin radiance from baseline",
    "Change in skin elasticity from baseline",
    "Change in skin thickness from baseline"
   ]
  },
  {
   "nct": "NCT07419854",
   "title": "Restoring Facial Volume After GLP-1 Weight Loss With Radiesse",
   "tests": "Radiesse (CaHA), hyperdiluted vs standard",
   "kind": "filler/biostimulator",
   "area": "face",
   "comparison": "randomized, untreated until month 6",
   "status": "RECRUITING",
   "study_type": "INTERVENTIONAL",
   "allocation": "RANDOMIZED",
   "enrollment": 48,
   "primary_completion": "2027-08",
   "sponsor": "Kalpna Kay Durairaj, MD, FACS",
   "sponsor_class": "OTHER",
   "has_results": false,
   "primary_outcomes": [
    "Change in Cheek Volume, as quantified by Quantificare's LifeViz Software",
    "Change in Jowl Volume, as quantified by Quantificare's LifeViz Software",
    "Change in Nasolabial Fold Depth, as quantified by Quantificare's LifeViz Software",
    "Change in Marionette Line Depth, as quantified by Quantificare's LifeViz Software",
    "Body Mass Index (BMI)",
    "Global Aesthetic Improvement Scale (GAIS) for Global Facial Aesthetic Appearance",
    "Global Aesthetic Improvement Scale (GAIS) for Skin Quality",
    "Global Aesthetic Improvement Scale (GAIS) for Skin Radiance"
   ]
  },
  {
   "nct": "NCT07221461",
   "title": "Assess Impact of Microdroplet Hyaluronic Acid Filler on Skin Quality in Patients on Glucagon-like Peptide-1 Agonists",
   "tests": "SKINVIVE (microdroplet HA)",
   "kind": "filler/biostimulator",
   "area": "face",
   "comparison": "non-GLP-1 group",
   "status": "NOT_YET_RECRUITING",
   "study_type": "INTERVENTIONAL",
   "allocation": "NON_RANDOMIZED",
   "enrollment": 24,
   "primary_completion": "2026-01-30",
   "sponsor": "Goldman, Butterwick, Fitzpatrick and Groff",
   "sponsor_class": "OTHER",
   "has_results": false,
   "primary_outcomes": [
    "Global Fine Lines",
    "Overall Hyperpigmentation",
    "Skin Tone Evenness",
    "Skin Firmness",
    "Skin Radiance/ Brightness",
    "Skin Texture Smoothness",
    "Global Wrinkles"
   ]
  },
  {
   "nct": "NCT07217743",
   "title": "Assess Impact of Poly-L-lactic Acid on GLP1 Subjects",
   "tests": "Sculptra (PLLA)",
   "kind": "filler/biostimulator",
   "area": "abdomen",
   "comparison": "none stated",
   "status": "NOT_YET_RECRUITING",
   "study_type": "INTERVENTIONAL",
   "allocation": "NON_RANDOMIZED",
   "enrollment": 20,
   "primary_completion": "2026-08-30",
   "sponsor": "Goldman, Butterwick, Fitzpatrick and Groff",
   "sponsor_class": "OTHER",
   "has_results": false,
   "primary_outcomes": [
    "Physical Global Aesthetic Improvement Scale"
   ]
  },
  {
   "nct": "NCT07478198",
   "title": "Study on the Efficacy and Safety of PLLA Injections for Improving Facial Laxity Following GLP-1 Analog Therapy",
   "tests": "PLLA injections",
   "kind": "filler/biostimulator",
   "area": "face",
   "comparison": "none",
   "status": "ENROLLING_BY_INVITATION",
   "study_type": "INTERVENTIONAL",
   "allocation": "NA",
   "enrollment": 22,
   "primary_completion": "2026-08-31",
   "sponsor": "Shanghai Punan Hospital of Pudong New District",
   "sponsor_class": "OTHER",
   "has_results": false,
   "primary_outcomes": [
    "WSRS (Wrinkle Severity Rating Scale) Assessment"
   ]
  },
  {
   "nct": "NCT07685834",
   "title": "Evaluation of Facial and Neck Skin Laxity With SofWave Treatment in Adults Initiating Tirzepatide for Weight Loss",
   "tests": "Sofwave ultrasound device",
   "kind": "device",
   "area": "face and neck",
   "comparison": "randomized, untreated",
   "status": "ACTIVE_NOT_RECRUITING",
   "study_type": "INTERVENTIONAL",
   "allocation": "RANDOMIZED",
   "enrollment": 30,
   "primary_completion": "2027-03-01",
   "sponsor": "Sofwave Medical LTD",
   "sponsor_class": "INDUSTRY",
   "has_results": false,
   "primary_outcomes": [
    "Improvement in the appearance of lax skin"
   ]
  },
  {
   "nct": "NCT07224880",
   "title": "Ellacor\u00ae Micro-Coring Technology\u00ae in Fitzpatrick Skin Types I-VI, Including Patients Receiving Glucagon-Like Peptide-1 Receptor Agonists",
   "tests": "ellacor micro-coring device",
   "kind": "device",
   "area": "face",
   "comparison": "none (observational)",
   "status": "COMPLETED",
   "study_type": "OBSERVATIONAL",
   "allocation": null,
   "enrollment": 9,
   "primary_completion": "2026-08-21",
   "sponsor": "Cytrellis Biosystems, Inc.",
   "sponsor_class": "INDUSTRY",
   "has_results": false,
   "primary_outcomes": [
    "Safety and Outcomes"
   ]
  },
  {
   "nct": "NCT07216352",
   "title": "Evaluate the Safety and Efficacy of a Topical Serum (AGE Serum) in Improving Visible Signs of Aging",
   "tests": "AGE Serum (topical)",
   "kind": "topical",
   "area": "face",
   "comparison": "none",
   "status": "NOT_YET_RECRUITING",
   "study_type": "INTERVENTIONAL",
   "allocation": "NA",
   "enrollment": 25,
   "primary_completion": "2026-03-30",
   "sponsor": "Goldman, Butterwick, Fitzpatrick and Groff",
   "sponsor_class": "OTHER",
   "has_results": false,
   "primary_outcomes": [
    "Modified Griffith Scale"
   ]
  },
  {
   "nct": "NCT07558603",
   "title": "Evaluate the Safety and Efficacy of AGE Serum in Post-menopausal Patients on Hormone Replacement Therapy Taking Glucagon-like Peptide-1 Agonist",
   "tests": "AGE Serum (topical), with vs without HRT",
   "kind": "topical",
   "area": "face",
   "comparison": "HRT vs no HRT",
   "status": "NOT_YET_RECRUITING",
   "study_type": "INTERVENTIONAL",
   "allocation": "NON_RANDOMIZED",
   "enrollment": 50,
   "primary_completion": "2026-08-30",
   "sponsor": "Goldman, Butterwick, Fitzpatrick and Groff",
   "sponsor_class": "OTHER",
   "has_results": false,
   "primary_outcomes": [
    "Modified Griffith Scale"
   ]
  },
  {
   "nct": "NCT07760532",
   "title": "Comparing Facial Aging Between Identical Twins With 3D Imaging",
   "tests": "none: one-visit 3D facial imaging of identical twins",
   "kind": "observational",
   "area": "face",
   "comparison": "within twin pair",
   "status": "NOT_YET_RECRUITING",
   "study_type": "OBSERVATIONAL",
   "allocation": null,
   "enrollment": 200,
   "primary_completion": "2026-09",
   "sponsor": "Ponsky Facial Aesthetics And Plastic Surgery, Llc",
   "sponsor_class": "INDUSTRY",
   "has_results": false,
   "primary_outcomes": [
    "Within-pair difference in quantitative three-dimensional facial surface measurements"
   ]
  }
 ]
}