{
 "page": "https://jabbitapp.com/research/vilon-vesugen-cartalax-bronchogen-khavinson-bioregulator-peptides-teardown.html",
 "checked": "2026-10-28",
 "note": "Quotes asserted against cached copies. PubMed name searches (vilon, vesugen OR vezugen, cartalax, bronchogen) run October 28, 2026; every record hand-classified by Jabbit as given to people, lab or animal study, or review; off-topic hits (surnames, bronchogenic cysts, unrelated chemistry) excluded and listed. 'Khavinson listed author' = an author last name beginning 'Khav' in the PubMed record (catches one misspelling); older records can omit authors, so this is a floor. Records can count under more than one peptide. X counts: recent-count endpoint, English, no reposts, query on the peptide names plus 'khavinson' and 'bioregulator(s)'; posters not named.",
 "pubmed_abstract_quotes": {
  "9637345": [
   "Pharmaceutical containing natural peptides (Thymalin) was put into practice as immunocorrector.",
   "A novel immunomodulatory dipeptide was synthesized and termed Vilon."
  ],
  "11140587": [
   "Subcutaneous administration of vilon (Lys-Glu) to female CBA mice starting from the 6th month of life increased physical activity and endurance, decreased body temperature, prolonged the lifespan, and prevented the development of spontaneous neoplasms.",
   "Vilon had no effect on age-related changes of estrous function and free radical processes."
  ],
  "19830585": [
   "It was shown that long-term treatment with some peptide preparations increased mean life span by 20-40%",
   "in rodents"
  ],
  "16075684": [
   "The obtained preliminary results of investigation suggest recommendation of Vilon application to increase 2-year survival of patients"
  ],
  "17152731": [
   "administration of thymomimetic Vilon (Lys-Glu) in these patients significantly reduces or even totally diminishes DIC syndrome"
  ],
  "18306698": [
   "the administration of Vilon as an addition to the complex therapy for this cohort of patients resulted in optimization of coagulation hemostasis"
  ],
  "25051774": [
   "Treatment results of erectile dysfunction in 41 patients were studied.",
   "A comparative analysis of clinical and instrumental parameters of blood flow in the main penile arteries before and after monotherapy was undertaken."
  ],
  "26390612": [
   "32 people (18 men, 12 women) aged 41-83 years",
   "At the same time we've found the prooxidant activity through chemiluminescence.",
   "Decrease of markers CD34+ positive hematopoietic polypotent cells in blood has shown significant inhibition of hemopoiesis.",
   "This property should be studied in future."
  ],
  "28539017": [
   "110 representatives of different age groups",
   "dry carbon dioxide baths, hyperbaric oxygen therapy, therapeutic massage"
  ],
  "28509489": [
   "small peptides (cytogens) used as geroprotectors in the system of preventive medical nutrition"
  ],
  "23734521": [
   "combined application of several cytogens (pinealon and vezugen)"
  ],
  "12881997": [
   "a bimodal curve with the second maximum were detected at super-low doses (10(-17)-10(-15) mol/l)",
   "Authors propose a hypothesis that for superlow concentrations the formation and distance transmission of a signal from ligand to a target cell without the formation of any ligand-receptor complex take place."
  ],
  "22117547": [
   "short biologically active peptides are able to penetrate into an animal cell and its nucleus",
   "bronchogen (Ala-Glu-Asp-Leu) bind preferentially with deoxyribooligonucleotides containing CNG sequence"
  ],
  "15105581": [
   "The effect of the synthetic peptide bioregulator Vilon on structural and facultative heterochromatin of cultured lymphocytes from old people has been studied."
  ],
  "26468022": [
   "Rats with Obstru"
  ],
  "19895477": [
   "A total of 228 dipeptides were synthesized",
   "intestinal permeability using Caco-2 cells",
   "postabsorptive ACE inhibitory activities of dipeptides in vivo are most likely limited due to the very low intestinal permeability of dipeptides"
  ]
 },
 "pmc8619776_quotes": [
  "KE, Vilon regulation of immune system function, antioxidant effect, stress-protective effect, geroprotection",
  "KED, Vesugen regulation of cardiovascular system function, neuroprotector",
  "AED, Cartalax regulation of cartilage and skin fibroblasts functions, neuronal cell differentiation",
  "AEDL, Bronchogen regulation of lung cells’ function and differentiation"
 ],
 "pmc9323678_quotes": [
  "when administered orally, peptides must be absorbed into the bloodstream through the intestinal barrier in their active forms. It is important to study the absorption mechanism of bioactive peptides",
  "KE peptide (to a greater extent) and AEDG peptide (to a lesser extent) were hydrolyzed in solutions and partially in tissues",
  "there is a high probability of their transport into cells of various organs and tissues with the participation of LAT1 transporter, POT family and L-system transporters",
  "Thymogen (EW) −24.72 Immunoprotector, medicinal product",
  "Saint Petersburg Institute of Bioregulation and Gerontology"
 ],
 "patent_quotes": {
  "US7851449B2": [
   "Peptide, pharmaceutical composition, and a method of treating microcirculation disorders",
   "1. An isolated peptide of the formula H-Lys-Glu-Asp-OH.",
   "SIA Peptides OOO",
   "Prior art date 2006-05-23",
   "Publication date 2010-12-14",
   "parenteral administration"
  ],
  "US6642201B1": [
   "Use of a dipeptide for stimulating repair processes",
   "Klinika Instituta Bioregulyatsii Gerontologii",
   "Prior art date 1998-06-23",
   "Publication date 2003-11-04",
   "parenteral, oral, intranasal or local"
  ]
 },
 "fda_safety_risk_page": {
  "name_counts": {
   "Vilon": 0,
   "Vesugen": 0,
   "Vezugen": 0,
   "Cartalax": 0,
   "Bronchogen": 0,
   "Lys-Glu": 0,
   "Khavinson": 0
  },
  "quotes": [
   "Compounded drugs containing epitalon may pose risk for immunogenicity",
   "Content current as of: 04/22/2026"
  ]
 },
 "clinicaltrials_gov": {
  "vilon": {
   "query.intr": 0,
   "query.term": 1
  },
  "vesugen": {
   "query.intr": 0,
   "query.term": 0
  },
  "cartalax": {
   "query.intr": 0,
   "query.term": 1
  },
  "bronchogen": {
   "query.intr": 1,
   "query.term": 1
  },
  "note": "Only non-zero hits are unrelated: NCT02580799 (vilon term), NCT06852014 (cartalax term), NCT00746759 (bronchogen; bronchoscopy study). ctgov_khavinson and ctgov_peptide_bioregulator: [0, 0]"
 },
 "drugs_at_fda": "openFDA drugsfda search: no matches for vilon, vesugen, cartalax, bronchogen",
 "x_daily_counts_utc": [
  [
   "2026-10-22",
   68
  ],
  [
   "2026-10-23",
   80
  ],
  [
   "2026-10-24",
   57
  ],
  [
   "2026-10-25",
   89
  ],
  [
   "2026-10-26",
   86
  ],
  [
   "2026-10-27",
   98
  ],
  [
   "2026-10-28",
   30
  ]
 ],
 "x_top_posts": [
  {
   "created_at_utc": "2026-10-23T16:18:38.000Z",
   "impressions": 241577
  },
  {
   "created_at_utc": "2026-10-20T13:26:28.000Z",
   "impressions": 848
  },
  {
   "created_at_utc": "2026-10-25T13:52:00.000Z",
   "impressions": 20854
  }
 ],
 "curation": {
  "vilon": {
   "pubmed_hits": 80,
   "excluded_off_topic": [
    "38032009",
    "36395816",
    "28959869",
    "28556182",
    "8378656",
    "1575790",
    "1780662",
    "1780649",
    "1647546"
   ],
   "relevant": 71,
   "given_to_people": [
    "16075684",
    "17152731",
    "18306698"
   ],
   "reviews": [
    "32362097",
    "25826983",
    "24003726",
    "19670728",
    "9637345"
   ],
   "lab_or_animal": 63,
   "khavinson_listed_author": 52,
   "years": [
    1997,
    2023
   ]
  },
  "vesugen": {
   "pubmed_hits": 27,
   "excluded_off_topic": [
    "29226462",
    "25702411"
   ],
   "relevant": 25,
   "given_to_people": [
    "25051774",
    "26390612",
    "28539017",
    "28509489",
    "23734521"
   ],
   "reviews": [
    "34173097"
   ],
   "lab_or_animal": 19,
   "khavinson_listed_author": 15,
   "years": [
    2008,
    2024
   ]
  },
  "cartalax": {
   "pubmed_hits": 6,
   "excluded_off_topic": [],
   "relevant": 6,
   "given_to_people": [],
   "reviews": [],
   "lab_or_animal": 6,
   "khavinson_listed_author": 5,
   "years": [
    2011,
    2020
   ]
  },
  "bronchogen": {
   "pubmed_hits": 12,
   "excluded_off_topic": [
    "20724242",
    "16637389",
    "2643787",
    "3185576",
    "13324990"
   ],
   "relevant": 7,
   "given_to_people": [],
   "reviews": [],
   "lab_or_animal": 7,
   "khavinson_listed_author": 4,
   "years": [
    2006,
    2017
   ]
  }
 },
 "union": {
  "distinct_relevant_records": 97,
  "khavinson_listed_author": 65,
  "in_bull_exp_biol_med_or_adv_gerontol": 70
 },
 "chart_data": {
  "evidence": [
   [
    "Vilon",
    3,
    63,
    5
   ],
   [
    "Vesugen",
    5,
    19,
    1
   ],
   [
    "Cartalax",
    0,
    6,
    0
   ],
   [
    "Bronchogen",
    0,
    7,
    0
   ]
  ],
  "khavinson": [
   [
    "Vilon",
    52,
    71
   ],
   [
    "Vesugen",
    15,
    25
   ],
   [
    "Cartalax",
    5,
    6
   ],
   [
    "Bronchogen",
    4,
    7
   ]
  ]
 }
}