{ "checked": "2026-10-26", "page": "https://jabbitapp.com/research/taurine-aging-longevity-inflammaging-evidence-teardown.html", "japan_drug": { "product": "Taurine Powder 98% \"Taisho\" (タウリン散98%「大正」)", "holder": "Taisho Pharmaceutical", "indications": [ "liver function in hyperbilirubinemia (excluding obstructive jaundice)", "congestive heart failure", "suppression of stroke-like episodes in MELAS (added 2019; orphan drug)" ], "pmda_review": "https://www.pmda.go.jp/drugs/2019/P20190215002/400059000_21900AMX00674_A100_1.pdf", "amed_release": "https://www.amed.go.jp/news/release_20190219-01.html", "quotes": [ "タウリン散98%「大正」", "大正製薬株式会社", "うっ血性心不全", "MELAS）症候群における脳卒中様発作の抑制", "希少疾病用医薬品", "平成 31 年１月 31 日", "1987年：うっ血性心不全", "タウリンは、日本で初めて、ミトコンドリア病の一種MELASに対して保険適用された治療薬となる予定です。", "平成31年1月31⽇" ] }, "efsa_2009": { "url": "https://www.efsa.europa.eu/en/news/efsa-adopts-opinion-two-ingredients-commonly-used-some-energy-drinks", "opinion": "https://doi.org/10.2903/j.efsa.2009.935", "quotes": [ "Published : 12 February 2009", "was not of safety concern", "This opinion evaluated the safety of these two ingredients as constituents of energy drinks, rather than energy drinks themselves" ] }, "news": { "yale_2026_10_23": { "url": "https://medicine.yale.edu/news-article/amino-acid-diminishes-age-related-inflammation/", "quotes": [ "In a new study published Oct. 23 in Cell , researchers at Yale School of Medicine found that the amino acid taurine is key to the way the innate immune system senses danger signals.", "By comparing the blood serum of young (20- to 40-year-old) and older (60- to 99-year-old) people, his team found that taurine actually increased with age.", "The finding was surprising and suggested that taurine does not drive aging", "Surprisingly, as the complexes were forming, macrophages released up to 80% of their taurine.", "Dixit first became interested in taurine after finding that it increased as people restricted their calorie intake for up to one year as part of the CALERIE study.", "whether these findings could translate to something that can benefit older adults", "supported by the National Institutes of Health" ] }, "columbia_2023_06_08": { "url": "https://www.eurekalert.org/news-releases/990909", "quotes": [ "taurine increased average lifespan by 12% in female mice and 10% in males", "The researchers started with close to 250 14-month-old female and male mice", "Only a randomized clinical trial in people will determine if taurine truly has health benefits, Yadav adds." ] } }, "registry": { "clinicaltrials_gov_intervention_taurine": 154, "note": "Broad search; includes energy-drink, multi-ingredient and infant-nutrition studies.", "selected": { "NCT00497978": [ "COMPLETED", 236, "Medical Center Alkmaar", "2011-10", false ], "NCT06613542": [ "COMPLETED", 90, "Technical University of Munich", "2025-11-13", false ], "NCT05149716": [ "COMPLETED", 24, "University of Sao Paulo", "2020-06-15", false ] } }, "pubmed": { "rct_query": "\"taurine\"[Title] AND \"randomized controlled trial\"[Publication Type]", "rct_count": 123, "lifespan_query": "\"taurine\"[Title/Abstract] AND (\"lifespan\"[Title/Abstract] OR \"longevity\"[Title/Abstract])", "lifespan_count": 76, "meta_query": "\"taurine\"[Title] AND (\"meta-analysis\"[Publication Type] OR \"systematic review\"[Title] OR \"meta-analysis\"[Title])", "meta_count": 29, "note": "We did not classify every record; we found no trial measuring human lifespan." }, "key_trials": [ { "trial": "Cirrhosis fatigue, 2026", "n": 220, "result": "Main goal missed", "design": "Open-label", "id": "42043864" }, { "trial": "Hip fracture, older adults, 2015", "n": 236, "result": "No fewer complications or deaths", "design": "Placebo", "id": "26035756" }, { "trial": "Prehypertension, 2016", "n": 120, "result": "Blood pressure lower", "design": "Placebo", "id": "26781281" }, { "trial": "Biological-age trial, 2024-25", "n": 90, "result": "Finished; no results posted", "design": "Placebo", "id": "NCT06613542" }, { "trial": "Women 55 to 70, 2022", "n": 24, "result": "Antioxidant marker held", "design": "Placebo", "id": "35700594" }, { "trial": "Heart failure, 1985", "n": 14, "result": "Symptoms improved", "design": "Placebo, crossover", "id": "3888464" }, { "trial": "MELAS, Japan, 2019", "n": 10, "result": "6 of 10 had no episodes", "design": "Open-label", "id": "29666206" } ], "key_trials_total_n": 714, "abstract_quotes": { "42914977": { "title": "Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages", "journal": "Cell", "year": "2026", "quotes": [ "Whether a decline in taurine drives aging is debated", "Here, we show that aging increases circulating taurine concentrations in humans and mice.", "Further elevating taurine in aged mice enhances health span", "reduces mortality from sepsis and inflammasome-mediated inflammation", "diverse NLRP3-specific \"danger signals\" induce taurine efflux from macrophages as a proximal step to activate the inflammasome", "In humans, sustained caloric restriction elevates adipose tissue taurine and is accompanied by lower inflammation.", "suggesting taurine-based strategies to alleviate inflammaging and inflammasomopathies" ] }, "37289866": { "title": "Taurine deficiency as a driver of aging", "journal": "Science", "year": "2023", "quotes": [ "We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans.", "increased the health span (the period of healthy living) and life span in mice and health span in monkeys", "In humans, lower taurine concentrations correlated with several age-related diseases", "Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans." ] }, "40472098": { "title": "Is taurine an aging biomarker?", "journal": "Science", "year": "2025", "quotes": [ "We found that circulating taurine concentrations increased or remained unchanged with age in three geographically distinct human cohorts as well as in nonhuman primates and mice", "Our results suggest that changes in circulating taurine are not a universal feature of aging" ] }, "40369079": { "title": "Taurine from tumour niche drives glycolysis to promote leukaemogenesis", "journal": "Nature", "year": "2025", "quotes": [ "These analyses identify the taurine-taurine transporter (TAUT) axis as a critical dependency of aggressive myeloid leukaemias.", "Blocking CDO1 expression in osteolineage cells impairs LSC growth and improves survival outcomes.", "identifies taurine as a key regulator of myeloid malignancies" ] }, "1138364": { "title": "Retinal degeneration associated with taurine deficiency in the cat", "journal": "Science", "year": "1975", "quotes": [ "A degeneration of the retinal photoreceptor cells develops in cats when casein is the source of dietary protein.", "selective decrease in plasma and retinal taurine concentrations" ] }, "3616607": { "title": "Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy", "journal": "Science", "year": "1987", "quotes": [ "Thousands of pet cats die each year with dilated cardiomyopathy, the cause of which is unknown.", "Oral supplementation of taurine resulted in increased plasma taurine concentrations and was associated with normalization of left ventricular function in both groups of cats." ] }, "3888464": { "title": "Therapeutic effect of taurine in congestive heart failure: a double-blind crossover trial", "journal": "Clin Cardiol", "year": "1985", "quotes": [ "14 patients with congestive heart failure for a 4-week period", "No patient worsened during taurine administration, but four patients did during placebo." ] }, "35855073": { "title": "Effect of taurine administration on symptoms, severity, or clinical outcome of dilated cardiomyopathy and heart failure in humans: a systematic review", "journal": "Wellcome Open Res", "year": "2022", "quotes": [ "it is currently unlicensed in Europe and the United States for human medical treatment", "Only one paper was deemed \"high quality\" using the NOQAS tool.", "no study was specific to DCM", "No significant safety concerns were reported.", "A formal clinical trial is needed" ] }, "29666206": { "title": "Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial", "journal": "J Neurol Neurosurg Psychiatry", "year": "2019", "quotes": [ "multicentre, open-label, phase III trial in which 10 patients with recurrent stroke-like episodes", "The proportion of patients who reached the primary endpoint (100% responder rate) was 60% (95% CI 26.2% to 87.8%).", "Taurine reduced the annual relapse rate of stroke-like episodes from 2.22 to 0.72 (P=0.001).", "No severe adverse events were associated with taurine." ] }, "26781281": { "title": "Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study", "journal": "Hypertension", "year": "2016", "quotes": [ "We randomly assigned 120 eligible prehypertensive individuals", "for 12 weeks", "Mean clinic systolic BP reduction for taurine/placebo was 7.2/2.6 mm Hg, and diastolic BP was 4.7/1.3 mm Hg." ] }, "41275513": { "title": "Effects of Oral Taurine Supplementation on Cardiometabolic Risk Factors: A Meta-analysis and Systematic Review of Randomized Clinical Trials", "journal": "Nutr Rev", "year": "2026", "quotes": [ "Thirty-four eligible RCTs were analyzed.", "systolic blood pressure (MD, -4.38 mmHg; 95% CI, -7.26 to -1.50)", "glycated hemoglobin A1c (MD, -0.21%; 95% CI, -0.37 to -0.05)", "Taurine supplementation may effectively improve cardiometabolic risk factors in adults" ] }, "39148075": { "title": "Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis", "journal": "Nutr J", "year": "2024", "quotes": [ "The analysis included a pooled sample of 808 participants from 20 randomized controlled trials.", "No significant adverse effects were observed compared to cont" ] }, "38755142": { "title": "Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials", "journal": "Nutr Diabetes", "year": "2024", "quotes": [ "Taurine supplementation exhibits positive effects on multiple MetS-related factors" ] }, "40320621": { "title": "Effects of taurine supplementation on cognitive function: a systematic review and meta-analysis of randomised controlled trials", "journal": "Int J Food Sci Nutr", "year": "2025", "quotes": [ "A total of 7 RCTs with 9 intervention trials involving 402 individuals were included.", "the findings of the present meta-analysis do not provide sufficient evidence to support the efficacy of taurine supplementation in enhancing cognitive function" ] }, "41750826": { "title": "Cognitive Effects of Taurine and Related Sulphur-Containing Amino Acids: A Systematic Review of Human Trials and Considerations for Plant-Based Dietary Transitions", "journal": "Foods", "year": "2026", "quotes": [ "Eight RCTs involving 244 healthy participants met the inclusion criteria.", "Most cognitive outcomes showed no effect.", "Trials that combined taurine with caffeine showed more reliable performance benefits, but they did not isolate taurine's independent effects." ] }, "40852891": { "title": "Does One Shot Work? The Acute Impact of a Single Taurine Dose on Exercise Performance: A Meta-Analytic Review", "journal": "Scand J Med Sci Sports", "year": "2025", "quotes": [ "23 eligible randomized trials (k = 69, N = 308)", "The overall certainty of evidence, assessed using GRADE, was rated low to very low" ] }, "35700594": { "title": "Taurine as a possible antiaging therapy: A controlled clinical trial on taurine antioxidant activity in women ages 55 to 70", "journal": "Nutrition", "year": "2022", "quotes": [ "A double-blind study was conducted with 24 women (61.4 ± 4.2 y", "for 16 wk", "Taurine supplementation prevented the decrease in the antioxidant enzyme SOD" ] }, "42043864": { "title": "A randomized controlled trial of L-taurine for fatigue in decompensated cirrhosis", "journal": "Hepatol Commun", "year": "2026", "quotes": [ "This single-center, parallel-arm, open-label randomized controlled trial", "Of 220 randomized patients, 202 completed the study", "L-taurine did not improve fatigue in unselected patients with decompensated cirrhosis.", "this finding should be considered hypothesis-generating", "Adverse events occurred in 11.8% of patients treated with taurine, all of which were mild." ] }, "26035756": { "title": "Effect of oral taurine on morbidity and mortality in elderly hip fracture patients: a randomized trial", "journal": "Int J Mol Sci", "year": "2015", "quotes": [ "A double blind randomized, placebo controlled, clinical trial was conducted on elderly hip fracture patients.", "Taurine supplementation did not improve in-hospital morbidity, medical comorbidities during the first year, or mortality during the first year.", "Taurine supplementation lowered postoperative oxidative stress" ] }, "42834262": { "title": "Genome-wide meta-analysis dissects the genetic basis and health implications of circulating taurine", "journal": "Funct Integr Genomics", "year": "2026", "quotes": [ "circulating taurine levels in 36,490 European individuals", "genetically predicted circulating taurine shows evidence consistent with potential causal impacts on cancers, hypertension, neurodevelopment", "highlights high-priority disease phenotypes requiring subsequent experimental validation" ] }, "2496406": { "title": "Taurine: an overview of its role in preventive medicine", "journal": "Prev Med", "year": "1989", "quotes": [ "Accordingly, proprietary milk formulas are now supplemented with taurine." ] }, "29631391": { "title": "Effects and Mechanisms of Taurine as a Therapeutic Agent", "journal": "Biomol Ther (Seoul)", "year": "2018", "quotes": [ "Today, taurine has been approved for the treatment of congestive heart failure in Japan" ] } }, "conflict_statements": { "42914977": "The authors declare no competing interests.", "37289866": "Columbia University has filed provisional patent applications for which VKY is an inventor.", "40369079": "The authors declare no competing interests.", "35855073": "J.S.W. has consulted for MyoKardia, Inc. and Foresite Labs.", "41750826": "received research funding from Viridian Nutrition for unrelated work on taurine", "42043864": "The authors have no conflicts to report." }, "analysis": { "note": "Jabbit analysis. Taurine is a sulfur-containing amino acid made in the body and found in meat, fish and dairy. In mice, a 2023 study reported 10-12% longer average life; whether blood taurine falls with age is disputed (2025 NIA-led and Oct 2026 Yale-led studies found it rises or stays flat). The Oct 23, 2026 Cell paper is a mouse and cell mechanism study linking taurine to the NLRP3 inflammasome. No human trial has measured lifespan; one 6-month biological-age trial finished in Nov 2025 with no results posted. Human trials are mostly small and short, with modest cardiometabolic signals in meta-analyses, no clear cognitive effect, and negative or mixed results in hip fracture and cirrhosis trials. It is a prescription drug in Japan for heart failure, a liver indication and MELAS. Short-term tolerability looks good; a 2025 Nature mouse and cell study raised a question about taurine and myeloid leukemia that has not been tested in people taking supplements." } }