Trial-extension data shows weight regain can happen after semaglutide withdrawal. A maintenance log keeps appetite, habits, and trend changes visible before memory smooths them over.
In the STEP 1 trial extension, participants discontinued semaglutide 2.4 mg and lifestyle intervention after 68 weeks. Over the following year, participants regained a substantial portion of prior weight loss and cardiometabolic improvements moved back toward baseline. The practical takeaway is not panic; it is that maintenance needs tracking.
| Tracking area | Why it matters |
|---|---|
| Weight trend | Use weekly trend, not daily noise. |
| Appetite return | Hunger, cravings, meal size, late-night eating, alcohol interest. |
| Habits | Protein, steps, lifting, meal planning, travel, sleep, stress. |
| Medication timeline | Last dose, pause, switch, restart, missed dose, clinician-directed changes. |
| Side effects changing | GI symptoms, fatigue, mood, HRV, sleep, constipation or reflux changes. |